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Serum Biomarker Discovery: Discovery Means Finding Things You Didn’t Expect

9 Agosto, 2016 @ 1:00 pm - 2:00 pm

Dra. Craig Dan Thulin

Utah Valley University Materials de Barcelona (ICMAB)

Resumen

We have developed a robust and reproducible way to identify biomarkers for human diseases within the blood serum, using discovery-based mass spectrometry of large-protein-depleted specimens.  We have applied the method to complications of pregnancy—including preterm birth and preeclampsia—and to Alzheimer’s disease, finding several markers for each of these conditions.  Though the method was developed to identify biomarker candidates among the low-molecular-weight serum proteome, lipids were not excluded during the preparation and many lipidomic biomarkers were subsequently observed.  Our method shows tremendous promise for identification of disease risk before the onset of clinical symptoms.  Additionally, the importance of lipidomics in preclinical characterization is underscored.

Detalles

Fecha:
9 Agosto, 2016
Hora:
1:00 pm - 2:00 pm
Evento Categoría:

Organizador

Comisión de seminarios del departamento de Química Biológica, FFyB
Teléfono:
4964-8289/90/91
Email:
semqb@qb.ffyb.uba.ar

Lugar

Aula de Química Biológica – Dpto de Química Biológica
Paraguay 2155 6º piso, ascensores de la izquierda
CABA, Buenos Aires 1113 Argentina
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Teléfono:
0114964-8289