En nuestro laboratorio buscamos comprender qué relaciones existen entre la secuencia de una proteína, la conformación, la dinámica y su actividad biológica.
Director: Javier Santos
Faraj SE, Roman EA, Aran M, Gallo M, Santos J. The Alteration of the C-terminal Region of Human Frataxin Distorts its Structural Dynamics and Function. FEBS J. (2014) Jun 12. doi: 10.1111/febs.12869. PubMed
Faraj SE, Venturutti L, Roman EA, Marino-Buslje CB, Mignone A, Tosatto SCE, Delfino JM, and Santos J. The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin.. FEBS OPEN BIO, (2013) Jul 24;3:310-20. PubMed
Roman EA, Faraj SE, Cousido-Siah A, Mitschler A, Podjarny A, Santos J. Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family. Biochim Biophys Acta. (2013). Jun;1834(6):1168-80. PubMed
Roman EA, Faraj SE, Gallo M, Salvay AG, Ferreiro DU, Santos J. Protein Stability and Dynamics Modulation: The Case of Human Frataxin. PLoS ONE (2012). 7(9): e45743. PubMed
Binolfi A, Fernández CO, Sica MP, Delfino JM, Santos J.Recognition between a short unstructured peptide and a partially folded fragment leads to the thioredoxin fold sharin g native-like dynamics. Proteins: Structure, Function, and Bioinformatics (2012) May;80(5):1448-64 PubMed