Mecanismos de acción de nuevos agentes antitumorales: péptidos quiméricos del IFNalfa2b, ftalocianinas y derivados sintéticos de penicilinas.
Directora: Leonor Roguin
Cárdenas, M.G., Zotta, E., Marder, M., and Roguin, L.P. In vitro induction of apoptosis and in vivo effects of a flavone nitroderivative in murine mammary adenocarcinoma cells. Int. J. Cancer (2009) 125: 222-228. PubMed
Blank, V.C., Peña, C., and Roguin, L.P. STAT1, STAT3 and p38MAPK are involved in the apoptotic effect induced by a chimeric cyclic interferon-alpha2b peptide Exp. Cell. Res. (2010) 316: 603-614. PubMed
Blank, V.C., Bertucci, L, Furmento, V.A., Peña, C., Marino, V.J., and Roguin, L.P. A chimeric cyclic interferon-alpha2b peptide induces apoptosis by sequential activation of phosphatidylinositol 3-kinase, protein kinase-Cdelta and p38 MAPK. Exp. Cell Res. (2013) 319: 1471-1481. PubMed
Marino, J., García Vior, M.C., Furmento, V., Blank, V.C., Awruch, J., and Roguin, L.P. Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phtalocianine phototoxicity. Int J Biochem Cell Biol (2013) 45: 2553–2562. PubMed
Furmento, V.A., Marino, J., Blank, V.C., and Roguin, L.P. The granulocyte colony-stimulating factor (G-CSF) upregulates metalloproteinase-2 and VEGF through PI3K/Akt and Erk1/2 activation in human trophoblast Swan 71 cells. Placenta (2014) 35:937-46. PubMed